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The introduction of nicotinamide to be a nicotine substitution in e-cigarette and smokeless products signifies a major regulatory obstacle for the FDA. Nicotinamide does not have nicotinic receptor agonist activity and is known to work as a sedative at high dosages6. The claims made by Nicotine River, ECBlend, and other distributors that their prod

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SVJ and SEJ: conceptualized and built the examine and drafted the manuscript. SEJ provided supervision. Both authors critically reviewed, edited and approved the ultimate Model of the manuscript.The ultimate rule also points out how applicants may perhaps submit a supplemental PMTA or even a resubmission, which might make improvements to performanc

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